| Pair Name | Propyl gallate, Cisplatin | ||
| Phytochemical Name | Propyl gallate (PubChem CID: 4947 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Propyl gallate, Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Target-->HO-1 | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| Down-regulation | Expression | HMOX1 | hsa3162 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | RNF139 | hsa11236 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | Our data provide the potential application of PG in combination chemotherapy to enhance drug sensitivity in lung cancer by targeting HO-1. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation. Eur J Pharmacol. 2016 Oct 5;788:321-327. doi: 10.1016/j.ejphar.2016.06.052. | Click |
